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SOCIAL DEFEATS INDUCE MODEST CHANGES IN SLEEP AND OPEN FIELD BEHAVIOUR IN RATS Kinn A, 1 Gronli J, 1, 2 Ursin R, 1, 2 Portas C1, 2 1 ; Dept. of Biomedicine, University of Bergen, Bergen, Norway, 2 ; Norwegian Competence Center for Sleep Disorders, Bergen, Norway Introduction : Depression in humans is associated with affective changes, sleep alterations e.g. altered rapid eye movement REM ; sleep, reduced delta sleep and fragmented sleep ; and psychomotor disturbance. Similar symptoms are also observed in animals after exposure to unpredictable stressors. Social defeat SD ; , resulting from the fight for a territory, has been used as an animal model of depression and anxiety. The model is based on the resident-intruder paradigm in which a male rat `intruder' is placed in the territory and defeated by an older, bigger and more aggressive male resident. We investigated whether SD, an animal model of depression and anxiety, would cause changes in sleep, emotionality locomotor activity in the defeated rat. Methods : Male Wistar rats were implanted with EEG and EMG electrodes. Rats were divided in a SD group n 8 ; exposed to 1h SD two subsequent days and a control group n 8 ; . all animals sleep was recorded the day before, 13h and 4 days after last SD confrontation. Behaviour of all animals was quantified in the open field test on four consecutive days starting at day 8 after last SD. Results : Defeated rats showed more fragmented sleep day 4 compared to baseline F 1, 6 ; 23.897, p 0.003 ; due to an increased amount of slowwave-sleep-1 p 0, 001 ; and slow-wave-sleep-2 episodes p 0.001 ; . However, the SD procedure did not produce any changes in REM sleep amount, REM sleep latency, or delta sleep. Defeated rats showed less activity in the central sector of the open field F 1, 14 ; 8.106, p 0.013 ; and had no significant decrease in defecation rate across days. This suggests that defeated animals had become more emotional. However, total locomotor activity in the open field was not affected by the SD procedure. Conclusion : The SD procedure resulted in modest sleep alterations and increased emotionality in rats. Support optional.

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