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27 23. McKay SM and McLachlan EM. Inflammation of rat dorsal root ganglia below a midthoracic spinal transection. Neuroreport 15: 1783-1786, 2004 Mulvany MJ and Halpern W. Contractile properties of small arterial resistance vessels in spontaneously hypertensive and normotensive rats. Circ Res 41: 19-26, 1977. Murthy VN, Schikorski T, Stevens CF and Zhu Y. Inactivity produces increases in neurotransmitter release and synapse size. Neuron 32: 673-682, 2001. Ralevic V and Burnstock G. Postjunctional synergism of noradrenaline and adenosine 5'-triphosphate in the mesenteric arterial bed of the rat. Eur J Pharmacol 175: 291-299, 1990 Stephens N, Bund SJ, Jagger C and Heagerty AM. Arterial neuroeffector responses in early and mature spontaneously hypertensive rats. Hypertension 18: 674-682, 1991. Stjernberg L, Blumberg H and Wallin BG. Sympathetic activity in man after spinal cord injury. Outflow to muscle below the lesion. Brain 109: 695-715, 1986. Taylor RB and Weaver LC. Spinal stimulation to locate preganglionic neurons controlling the kidney, spleen, or intestine. J Physiol 263: H1026-H1033, 1992. 30. Teasell RW, Arnold JM, Krassioukov A and Delaney GA. Cardiovascular consequences of loss of supraspinal control of the sympathetic nervous system after spinal cord injury. Arch Phys Med Rehabil 81: 506-516, 2000. Trendelenburg U, Maxwell RA and Pluchino S. Methoxamine as a tool to assess the importance of intraneuronal uptake of l-norepinephrine in the cat's nictitating membrane. J Pharmacol Exp Ther 172: 91-99, 1970. Vaidyanathan S, Soni BM, Sett P, Watt JW, Oo T and Bingley J. Pathophysiology of autonomic dysreflexia: long-term treatment with terazosin in adult and paediatric spinal.

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13 Langer SZ. Nomenclature and state of the art on 1-adrenoceptors. Eur Urol 1998; 33 suppl 2 ; : 26. 14 Martin DJ, Angel I, Arbilla S. Functional uroselectivity. Eur Urol 1998; 33 suppl 2 ; : 1218. 15 Palea S, Barras M, et al. Antagonist effects of alfuzosin on concentration-response curves to phenylephrine and noradrenaline in human prostatic adenoma. Neurourol Urodyn 2000; 19: 43133. Muramatsu I, Taniguchi T, Okada K, et al. Tamsulosin, alpha1-adrenoceptor subtypeselectivity and comparison with terazosin. Jpn J Pharmacol 1998; 78: 33135. Teng C-M, Guh J-H, Ko F-N. Functional identification of 1-adrenoceptor subtypes in human prostate: comparision with those in rat vas deferens and spleen. Eur J Pharmacol 1994; 265: 6166. Ishikawa H, et al. Comparison of post-junctional alpha-adrenoceptors in iris dilator muscle of humans, and albino and pigmented rabbits. Naunyn Schmiedebergs Arch Pharmacol 1996; 354: 76572. Honda K, Nakagawa C. Alpha1-adrenoceptor antagonist effects of the optimal isomers of YM-12617 in rabbit lower urinary tract and prostate. JPET 1986; 239: 51216. Takayanagi I, et al. A difference in mode of antagonism between optical isomers of a potent selective alpha 1-adrenoceptor blocker YM-12617 ; and norepinephrine in isolated rabbit iris dilator and aorta. Jpn J Pharmacol 1986; 42: 57982. Fanciullacci M, Sicuteri R, Alessandri M, et al. Buspirone, but not sumatriptan, induces miosis in humans: relevance for a serotoninergic pupil control. Clin Pharmacol Ther 1995; 57: 34955. Yu Y, Ramage AG, Koss MC. Pharmacological studies of 8-OH-DPAT-induced papillary dilation in anesthetized rats. Eur J Pharmacol 2004; 489: 20713. Pringle E, Packard R. Antipsychotic agent as an etiologic agent of IFIS. J Cataract Refract Surg 2005; 31: 2240. Giuliano F. Impact of medical treatments for benign prostatic hyperplasia on sexual function. BJU Int 2006; 97 suppl 2 ; : 3438 and ultram.
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Since low pressure HBOT under 1.5 ATA ; improved symptoms in some patients with cerebral hypoperfusion disorders [1315, 65], it was hypothesized that low pressure HBOT would also help autism, a disease in which cerebral hypoperfusion is an integral component [31, 32]. Recently, evidence has accumulated that low pressure hyperbaric therapy at 1.3 ATA and less than 100% delivered oxygen may improve symptoms in some diseases associated with cerebral hypoperfusion. For instance, one study using hyperbaric therapy at 1.3 ATA and room air demonstrated clinical improvements in some children with CP [129, 130], a disease shown to have evidence of diminished cerebral blood flow [75]. Furthermore, one case report indicated ``striking improvement'' in a 4 year old child with autism after using hyperbaric therapy for 10 sessions at 1.3 ATA and room air. The child also had improvement of cerebral hypoperfusion as measured by pre-HBOT and post-HBOT SPECT scans [78]. Based upon these findings, it was hypothesized that low pressure HBOT would improve symptoms of autism. A retrospective case series was examined to evaluate this hypothesis. A review of the medical literature was performed using MEDLINE and Google Scholar and no clinical studies were found on the use of HBOT in autistic children!


Bjp 07192; published online 12 march 2007 cardiovascular and pulmonary pharmacology pharmacokinetic and pharmacodynamic consequences of inhibition of terazosin metabolism via cyp3a1 and or 3a2 by da-8159, an erectogenic, in rats e y oh bae 1 , j w kwon 2 , m you 2 , d c lee 3 and m g lee 1 college of pharmacy and research institute of pharmaceutical sciences, seoul national university, kwanak-gu, seoul, south korea 2 research laboratory, dong-a pharmaceutical company, ltd, kyunggi-do, south korea 3 department of family medicine, youngdong severance hospital, college of medicine, yonsei university, kangnam-gu, seoul, south korea correspondence: professor mg lee, college of pharmacy and research institute of pharmaceutical sciences, seoul national university, san 56-1, shinlim-dong, kwanak-gu, seoul 151-742, south korea.

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