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R. S. LABOW AND D. S. LAYNE for glycoside formation as described above was limited by the specific radioactivity of the labelled aglycones, which for the isofiavones was low, and by the sensitivity of the colorimetric assay for p-nitrophenol Patel & Tappel, 1969 ; . The availability of UDP-D-[6-3H]glucose of high specific radioactivity 5.1 Ci mmol; Amersham Searle Corp., Chicago, Ill., U.S.A. ; permitted the incorporation of this material, diluted as required with the unlabelled nucleotide, into the incubation medium. Glucoside formation could therefore be measured as the amount of 3H-labelled glycoside formed rather than by difference from the amount of labelled aglycone that remained after the incubation. The extraction of 3H with ethyl acetate after the incubations was found to be a reliable measure of glycoside formation. Labelled glucose and excess of UDP-glucose remained in the aqueous medium. However, both the ethyl acetate extracts and the aqueous residues were examined by t.l.c. as a final check on the assay procedure. The evidence for the formation of the glucosides shown in Tables 1 and 2 was obtained with labelled UDP-glucose. The incubation procedure was identical with that already described, except that the UDPglucose added to each tube had a specific radio and anacin.
The size of India's pharmaceutical market may not be impressive by developed country standards, but it is still one of the largest markets by volumes. The domestic pharmaceutical market was valued at US$ 4.3 billion, with a year-on-year growth of 7.3 per cent AC Nielsen ORG Marg March 2004 ; . Some key segments that outperformed the broad market growth were anti-diabetes 11.6 per cent ; , cephalosporins 11.2 per cent ; , cough and cold preparations 9.0 per cent ; , analgesics 10.8 per cent ; and anti-epileptics 12.9 per cent ; , besides others. With the patent regime effective from January 2005 nearing, a number of companies initiated measures to introduce new products in India. Meanwhile, Indian companies with a strong focus on research, accelerated their product development within India, resulting in the introduction of value-added products on NDDS platforms. The Indian pharmaceutical industry is admired the world over. There are a number of reasons why the industry is becoming increasingly visible: India is being widely recognised as a low cost and high quality global pharmaceutical manufacturing base, which could accelerate outsourcing possibilities. The industry saw the emergence of cost-effective API manufacturers, with the ability to develop products through non-infringing processes, which provided an option to generic majors and innovators to outsource their manufacturing activities for some products.

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3.2.7.1 Current Status Provincial Territorial Local Most communication activities around influenza take place immediately preceding, and during, the typical influenza season from October to May each year. P Ts produce materials to promote immunization each fall which are specific to the program they are offering in their jurisdiction. Most communication materials and strategies targeting the general public, media, health care workers and other community organizations considered to be "external" key audiences ; are geared at promoting immunization and reducing unnecessary hospital visits. These materials are developed at the P T and local level with minimal federal input. To date, there has not been a centrally coordinated education campaign regarding pandemic influenza which targets the external key audiences. F P T secure website has been set-up to facilitate pandemic planning and sharing of key resources among recognized stakeholders. The role of this website as a communication tool will likely be expanded during the pandemic. Communication with "internal key audiences", mainly government decision makers and policy advisors, occurs at all levels of government. With respect to pandemic planning, the Pandemic Influenza Committee, which includes P T representation, reports through the Advisory Committee on Population Health and Health Security to the Conference of Deputy Ministers. In addition, in February 2002 the role of Chief, Crisis Communications was established by Health Canada. This office is working on an "all-hazards approach" which is establishing protocols for F P T interaction. One initiative was the creation of a network of F P communications contacts. This network was mobilized in during in response to the SARS outbreak and continues as a key component in communication planning for pandemic influenza and other health emergencies. Federal Federal communications on influenza currently focus on the dissemination of surveillance data, through FluWatch bulletins, which are directed to public health professionals but available to the public through the Health Canada website. These bulletins are produced on a weekly basis throughout the influenza season. Information regarding international influenza activity is disseminated by CIDPC, mainly through email or website postings, to key stakeholders as necessary. As well, fact sheets on influenza, including influenza vaccines, are posted on the Health Canada Website. Health Canada also communicate with "international key audiences" including the WHO and PAHO regarding influenza activity within and outside of Canada. For emergency situations Health Canada does have a public information line which can be set up for "around -the-clock" coverage. Other communication issues are also being addressed as part of the "all-hazards approach" to crisis communications.

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TABLE 3. NUCLEOTIDE DIVERSITY OF HVR1 SEQUENCES AT INDICATED TIMES FROM PATIENT 1 ON INTERFERON MONOTHERAPY: EVOLUTIONARY DISTANCES DETERMINED BY KIMURA-2 DISTANCE 0 hr Distance within group ; , mean SE 0.008 0.003 12 hr 0.001 24 hr 0.008 0.004 5 days 0.007 0.004 10 days 0.014 0.005.

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