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Appendix C DRAFT DOCUMENT AWAITING DRC APPROVAL ON APRIL 14, 2005 Arkansas Medicaid Prior Authorization Program Drug Review Committee Minutes for March 18, 2005 Members Present: Jill Johnson, Pharm. D.; Ted Lancaster, MD; Roberta Monson, MD; Kathryn Neill, Pharm. D.; Henry Simmons, Jr., MD, Ph.D. Members Absent: C.A. Kuykendall, PD and Josh O'Neill, MD. I. Dr. Simmons called the meeting to order at 10: 00. II. OLD BUSINESS OUTSTANDING REPORTS The Committee reviewed the minutes of the February 18 meeting and voted to accept them after receipt of a motion and second. III. NEW BUSINESS A. Item: Public presentations about the calcium channel blockers The Committee heard from Drs. Maurice Rozek and Rick Learned of Pfizer for Caduet; Dr. Glen Lepard of First Horizon for Sular; and Dr. Harold Betton of the Betton Clinic who had been sponsored by Biovail for Cardizem LA Presenters also answered questions from Committee members and submitted other information in either printed or electronic form. B. Item: Conflicts of interest Each Committee member reviewed and signed a conflict of interest statement specific to the statins. C. Item: Dr McDonaugh of the EPC telephonically presented an overview of her organization's impressions on the state of the literature regarding the statins, audited the Committee's deliberations and answered questions. E. Item: The Committee considered a series of questions regarding the potential toxicity and therapeutic roles of atorvastatin, fluvastatin, lovastatin, pravastatin, rosuvastatin and simvastatin as used to manage common conditions in adults. Their conclusions and the results of votes taken on various motions follow. 1. Does the bulk of the available evidence suggest that the aforementioned statins differ significantly in either the incidence or nature of clinically evident complications in patients of a particular sex, age or race? None of the six drugs differ significantly in either the incidence or the nature of clinically evident complications in patients of a particular sex, age or race when appropriately dosed. Dr. Neill made a formal motion to so notify DHS and the DUCC that was seconded by Dr. Monson. The motion passed unanimously. 2. Does the bulk of the available evidence suggest that one or more of the remaining statins are more efficacious for patients of a particular sex, age or race? None of the six drugs have been proven more efficacious for patients of a particular sex, age or race. Dr. Monson made a motion to so notify DHS and the DUCC that was seconded by Dr. Neill. The motion passed unanimously.
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In another aspect, the present invention provides a method for analyzing a sample of rosuvastatin comprising the steps of: a ; performing chromatography on the sample to obtain data; and b ; comparing the data with the chromatography data of thedegradation product.
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Ezetimibe in patients at high risk of cardiovascular disease results from the EXPLORER Study ; . J Cardiol. 2007 Mar 1; 99: 673-680. Epub 2007 Jan 4. 19. Ballantyne CM, Houri J, Notarbartolo A, et al, Ezetimibe Study Group. Effect of ezetimibe coadministered with atorvastatin in 628 patients with primary hypercholesterolemia: a prospective, randomized, double-blind trial. Circulation. 2003; 107: 2409-2415. Bottorff MB. Statin safety: what to know. J Geriatr Cardiol. 2004; 13 3, suppl 1 ; : 34-38. 21. Krasuski RA, Doeppenschmidt D, Henry JS, et al. Conversion to atorvastatin in patients intolerant or refractory to simvastatin therapy: the CAPISH study. Mayo Clin Proc. 2005; 80: 1163-1168. Waters DD. Safety of high-dose atorvastatin therapy. J Cardiol. 2005; 96 5A ; : 69F-75F. 23. Lavie CJ. Assessment and treatment of lipids in elderly persons [editorial]. J Geriatr Cardiol. 2004; 13 3, suppl 1 ; : 2-3. 24. Alsheikh-Ali AA, Ambrose MS, Kuvin JT, Karas RH. The safety of rosuvastatin as used in common clinical practice: a postmarketing analysis. Circulation. 2005 Jun 14; 111: 3051-3057. Epub 2005 May 23. 25. McKenney JM, Davidson MH, Jacobson TA, Guyton JR. Final conclusions and recommendations of the National Lipid Association Statin Safety Assessment Task Force. J Cardiol. 2006 Apr 17; 97 8A ; : 89C-94C. Epub 2006 Feb 28. 26. Kasiske BL, Wanner C, O'Neill WC. An assessment of statin safety by nephrologists. J Cardiol. 2006 Apr 17; 97 8A ; : 82C-85C. Epub 2006 Feb 9.

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Quality assessment of the model The quality of the model was evaluated using following means. Ramachandran plot shows that more than 97.9% of the angles of the residues are located in the favoured and most favoured regions Figure 3 ; . According to PROCHECK the optimised model shows relatively good protein geometry, and most of the quality parameters being better than average or in the range of tolerance thresholds ; . Although no clashes between residues of the model have been identified by DeepView, there were total of 41 marginally bad contacts between atoms of the minimised model listed by PROCHECK. The distances between the contacting atoms ranged from 2.3 to 2.6 and all of them were removed upon MD simulation. The reliability of protein folding appears to be good because the secondary structures are stable during molecular dynamics simulation Table 4 ; and the RMSD deviation between the starting model and the model after 60 ps free MD simulation is 1.67 which is less than the resolution 2.1 ; at which the template structure has been solved by X-ray crystallography. The third domain of AO Mo-Pt domain ; was uploaded to Verify-3D server 46, 47 ; to analyse the compatibility of the residues with their environment in the model. The result obtained is shown in figure 4. As it can be seen from the figure there is no residue with the negative compatibility score, which indicates the proper fold for the model. The result from Verify-3D is in agreement with the result obtained from THREADER 39 ; , another inverse protein folding method. The z-score calculated by THREADER for threading the sequence of AO onto the structure of XDH was 5.69 which is well above. Twice a year -- right before my birthday and on Christmas Eve -- I climb on a chair, fetch a dusty Adidas shoebox from a shelf and lay out ancient black-and-white photos from Russia on the dinner table, noticing that the glossy paper has collected some tan in the corners. One day, in the year, say, 2012, I'll be spreading this ritual solitaire over a bluish tablecloth, and my teenage daughter will storm out of her room, head in earphones, look at the collection and ask with lukewarm curiosity, "How do you get them to be black and white like that?. Florida Administrative Weekly DEPARTMENT OF BUSINESS AND PROFESSIONAL REGULATION Board of Professional Geologists RULE TITLE: RULE NO.: Procedures for Signing and Sealing Geological Papers, Reports, or Other Documents 61G16-2.005 PURPOSE AND EFFECT: The proposed rule will clarify those geological papers, reports, or other documents which are required to be signed, dated, and sealed by the professional geologist who actually prepared them or who had direct responsibility for the supervision, direction, or control of their preparation. In addition, the proposed rule will set forth an acceptable method whereby professional geologists may sign, date, and seal a geological paper, report, or other document which is transmitted through electronic means. SUBJECT AREA TO BE ADDRESSED: Procedures for Signing and Sealing Geological Papers, Reports, or Other Documents. SPECIFIC AUTHORITY: 282.75, 492.104, 492.107 FS. LAW IMPLEMENTED: 282.75, 492.107 FS. IF REQUESTED IN WRITING AND NOT DEEMED UNNECESSARY BY THE AGENCY HEAD, A RULE DEVELOPMENT WORKSHOP WILL BE NOTICED IN THE NEXT AVAILABLE FLORIDA ADMINISTRATIVE WEEKLY. THE PERSON TO BE CONTACTED REGARDING THE PROPOSED RULE DEVELOPMENT AND A COPY OF THE PRELIMINARY DRAFT, IF AVAILABLE, IS: D. A. O'Connor, Executive Director, Board of Professional Geologists, Northwood Centre, 1940 N. Monroe Street, Tallahassee, Florida 32399-0750 THE PRELIMINARY TEXT OF THE PROPOSED RULE DEVELOPMENT IS: 61G16-2.005 Procedures for Signing and Sealing Geological Papers, Reports, or Other Documents. 1 ; All geological papers, reports, or other documents prepared or issued by a licensed professional geologist shall be signed, dated, and sealed by the professional geologist who actually prepared the geological papers, reports, or documents or who had direct responsibility for the supervision, direction, or control of their preparation. 2 ; Geological papers, reports, or other documents shall mean any document, whether in a physical or electronic format which conveys or expresses an opinion, conclusion, interpretation, or recommendation based upon the performance of geological services. 3 ; Except as noted below, all geological papers, reports, or other documents which are required to be signed, dated, and sealed under the provisions of Chapter 492, F.S., shall bare the actual signature of the professional geologist who prepared or.

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