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Ms. Foreman: That's Fosamax? Dr. Khosla: Ffosamax that it was well tolerated, that there seemed to be a consistent effect on fracture risk reduction and at least in that trial, there weren't any really adverse effects that were noted in terms of the jaw osteonecrosis or delayed fracture healing and so forth, although the study may not have been large enough to pick up some of the rare side effects. So I think, again, in the absence of those kinds of data, it becomes a matter of clinical judgment and hopefully ongoing surveillance for these problems over time. And many of us are in the past, they were largely used in much older women, but as fewer and fewer women are using estrogen, more are likely to be candidates for bisphosphonates or other related drugs. And I think most of us are taking the position that if we start a younger women, let's say in her 50s or 60s on a bisphosphonate, that we would aim, perhaps, to great for about five years and sort of think in five-year windows because there are going to be newer drugs available, we'll be learning more about the potential side effects. So I don't think any of us is comfortable committing a person to 30 years of therapy with a bisphosphonate.
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FDA Patent Exclusivity Drug Chemical Approval Expiration Expiration Amoxil Amoxicillin 1982-1999 None None Augmentin Amoxicillin + Clavulanate 1984-2002 None None Avandia Rosiglitazone Maleate 1999 2008-2015 2003-2004 Becotide Beclovent Beclomethasone 1982 None None Combivir Lamivudine + Zidovudine 1997 2005-2018 None Coreg Carvedilol 1995-1997 2007-2016 2004 Epivir Lamivudine 1995-1998 2009-2018 2002-2005 Flixonase Flonase Fluticasone 1994 2003 2005 Flixotide Flovent Fluticasone 1993-1997 2003 None Fortum Fortaz Ceftazidime 1985-1989 None None Hepatitis Vaccines N A N Hycamtin Topotecan 1996 2010 None Imigran Imitrex Sumatriptan 1992-1997 2006-2013 None Diptheria + Tetanus Toxoid + Pertussis Vaccine N A N Infanrix Lamictal Lamotrigine 1994-1998 2008-2012 2005 Naramig Amerge Naratriptan 1998 2010 2003 Relafren Nabumetone 1991 2002-2003 None Requip Ropinirole 1997-1999 2007 None Retrovir Zidovudine 1987-1996 2005 None Seretide Advair Fluticasone + Salmeterol 2000 2003-2011 2003 Serevent Salmeterol 1994-1997 2008-2011 2003-2005 Seroxat Paxil Paroxetine 1992-2000 2006-2019 2002-2005 Trizivir Abacavir + Lamivudine + Zidovudine 2000 2005-2016 2003-2004 Valtrex Valacyclovir 1995 2009-2016 2004 Ventolin Albuterol 1982-1991 2012 None Wellbutrin Bupropion 1985-2002 2004-2013 2004 Zantac Ranitidine 1983-1994 2002-2009 2002-2003 Zeffix Lamivudine 1995-1998 2009-2018 2002-2005 Ziagen Abacavir 1998 2009-2018 2003-2004 Zinnat Ceftin Cefuroxime Axetil 1987-1997 None None Zofran Ondansetron Hydrochloride 1991-1999 2005-2015 None Zovirax Acyclovir 1982-1991 None None Zyban Bupropion 1997 2004-2013 2002 Actimmune Interferon Gamma-1B N A N A Aciphex Pariet Rabeprazole 2002 2008-2009 2004-2005 Contraceptives N A N Duragesic Fentanyl 1990 2004 None Eprex Procrit Epoetin Alfa N A N Floxin Levaquin Ofloxacin 1990-1997 2003-2012 None Remicade Infliximab N A N Risperdal Risperidone 1993-1999 2007-2014 2005 Sporanox Itraconazole 1992-1997 2005-2019 2004 Topamax Topiramate 1996-1998 2003 2002-2008 Ultram Ultracet Tramadol 1995 2019-2020 2002-2003 Altace Ramipril 1991 2005-2008 2003 Levoxyl Levathyroxine 2001 None None Thrombin-JMI Thrombin N A N Avinza Morphine 2002 2017 2005 Ontak Denileukin Diftitox N A N Targretin + Panretin Gel Bexarotene + Alitretinoin 1999-2000 2012-2016 2003-2006 Targretin Capsules Bexarotene 1999-2000 2012-2016 2003-2006 Ethyol Amifostine 1995 2012-2017 2002-2006 Synagis Palivizumab N A N Aggrastat Tirofiban 1998 2010-019 2003 Arcoxia Etoricoxib Not Approved Cancidas Caspofungin 2001 2013-2017 2006 Cozaar Hyzaar Losartan 1995 2009-2014 None Crixivan Stocrin Indinavir 1996 2012 None Fosamaax Alendronate 1995 2007-2015 2002-2003 Hepatitis Vaccines N A N Invanz Ertapenem 2001 2013-2017 2006 Major Drug Database. 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