
Table of Contents Compensation Committee Report on Executive Compensation The compensation committee has the responsibility for reviewing and approving the compensation of our Chief Executive Officer and other executive officers, including approving any performance objectives relevant to our executive officers' compensation and evaluating the achievement of those objectives. The committee also administers and approves awards under our equity incentive plans and reviews and recommends to our board of directors our executive officer compensation policies and practices generally and our director compensation program. The specific duties and responsibilities of the committee are described under "-- Committees of the Board of Directors -- Compensation Committee" and in the charter of the committee, which is available on our website at alphanr . The committee was formed by our board of directors in February 2005, prior to our initial public offering. The committee was initially comprised of four members, including E. Linn Draper, Jr., and John W. Fox, Jr., who have been determined by our board of directors to be independent under the New York Stock Exchange listing standards, and Alex T. Krueger and Hans J. Mende. In connection with our 2005 annual meeting of stockholders in April, 2005, Mr. Mende left the committee, such that a majority of the committee members were independent. In connection with the Resale Offering in January, 2006, Mr. Krueger resigned from the board of directors and newly elected independent director Ted G. Wood joined the committee, such that all current members of the committee are independent. The committee met six times and acted by unanimous written consent on two occasions during 2005. The committee's meetings typically last several hours, and all committee members are actively engaged in the review of matters presented. The committee's efforts during 2005 were focused on crafting compensation policies and practices designed to help us succeed as a public company in the highly competitive market for U.S. coal mining talent. The committee retained an outside compensation consultant, Mercer Human Resource Consulting, and also utilized the services of Deloitte Consulting LLP during 2005 to provide the committee with survey data and other information to assist the committee in establishing and implementing its overall compensation philosophy, independent of management. The members of the compensation committee are committed to attracting and retaining talented and motivated management and employees, which we believe is essential to creating long-term shareholder value. The committee has furnished the following report for 2005, which includes a discussion of our compensation and benefits programs during 2005, including compensation and benefits for our executive officers and Chief Executive Officer compensation in particular. Objective of Our Executive Compensation Program The fundamental objective of our executive compensation program is to attract, retain and motivate key executives to enhance long-term profitability and stockholder value. We achieve this objective by: Providing compensation that is targeted to be comparable to the compensation provided by a peer group composed primarily of similarlysized publicly-traded coal, energy and mining companies, in order to be competitive with our peer group; Providing compensation that is contingent upon remaining in our employ for a number of years, in order to encourage our executives to remain with us; Linking significant elements of executive compensation to the achievement of pre-established operating and financial objectives, in order to motivate our executives to enhance our profitability; and Rewarding executives for both short-and long-term enhancement of stockholder value, in order to align the interests of our executives with those of our stockholders. The peer group used by the committee in 2005 for comparisons is composed primarily of publicly-traded coal, energy and mining companies. The majority of the companies in the peer group used by the committee were part of the Russell 3000 Index shown in the stock performance chart that follows this report, and all of the coal companies in the peer group used by the committee were part of the Russell 3000 Coal Index shown in the stock performance chart. 20.
Duricef product monographADVISORY BOARD Why do benzoyl peroxides prevent drug resistance? WEBSTER Because they are antiseptics not antibiotics. Benzoyl peroxide is an oxidizing agent that generates a lot of peroxide most bacteria are simply not capable of standing up to. By effectively reducing the total number of bacteria, you naturally have a lower probability of fostering a mutation that is resistant. In addition, even if you have resistance present, you're not dealing with the selective force of 1 antibiotic that they can grow through. ADVISORY BOARD Does the old adage that you have to make the skin "red and dry" with benzoyl peroxide for it to be effective have any merit? WEBSTER That rationale harkens back to the days when acne was treated with peels and benzoyl peroxide was used as a peeling agent. Studies have since demonstrated that the main mechanism of action is the killing of P acnes and the weakest available benzoyl peroxide formulation is as effective as the strongest. As a result, concentration of the benzoyl peroxide should no longer be regarded as the, for example, amoxycillin.Duricef coverageCounsel women about good nutrition and eating foods that contain iron, folate, vitamin A, calcium, and iodine and avoiding tobacco, alcohol, and drugs except medications recommended by a health care provider ; . Help pregnant women protect themselves from infections and cefdinir. | Duricef and birth control pillsYou need to graduate from college, then medical school, then complete.Adjunct medications "Helper drugs" that not only relieve pain but can help other pain-fighting drugs work better. These drugs help relieve pain by controlling the source of the pain, rather than dulling the sensation of pain. breakthrough pain Pain flares that come on suddenly and "break through" chronic pain medication. These episodes can be controlled with short-acting pain relievers. end-of-dose failure A type of breakthrough pain, caused when long-acting medication wears off. incident pain A type of breakthrough pain, caused by activity. For example, people with hip problems may be comfortable while sitting, but pain occurs when they rise up from a chair. long-acting opioids Drugs used for pain that persists 12 hours or more each day. opioids Drugs used to treat moderate to severe pain. peripheral neuropathy A type of nerve damage that can have various causes, including some cancer treatments. It may be felt as tingling, weakness, or numbness in the hands and feet. short-acting opioids Drugs taken for sudden flare-ups or breakthrough pain. spontaneous pain A type of breakthrough pain, caused by no apparent reason. Can come on very suddenly, even if the person is doing nothing. vertebrae The bones making up the spinal column. When a growing cancer invades the vertebrae, they can collapse and press on nerves, causing back pain and omnicef, because chlamydia. C. EDUCATION CME GME The Center continues to be involved in teaching medical students, residents and fellows. Over the last 12 months, the Center has been the site for research mentorship of 4 students, 3 medical students, our Chief Resident Chin Hee Kim, MD ; , as well as one of our young staff hospitalist physician Dr. Ravi Gupta ; . Additionally, the Center has provided hepatology teaching to the gastroenterology fellows from George Washington University. Furthermore, Dr. Silvia Bondini from University of Bolognia spent a year sponsored by the University of Bolognia ; at the Center as the hepatology research fellow under the mentorship of Dr. Younossi. Since August 2006, Dr. Poonam Mishra has been working at the Center as the clinical and research hepatology fellow. In addition to teaching, Dr. Younossi has been involved in a number of CME programs aimed at enhancing educational opportunities of medical staff. These activities include sponsoring Medical Grand Rounds, conferences and seminars. Although some of these programs were local, others were national and international meetings. Finally, the Center was the main sponsor of the first Inova-GMU joint seminar "TRC's "Creating the Next Revolution in Molecular Medicine: Application of Translational Research in Clinical Medicine", which was successfully carried out in the Spring of 2006. The second InovaGMU joint annual seminar is scheduled for April of 2007. The following paragraphs archive the academic productivity of the CLD in terms of publications, and presentations at local national international meetings. D. PUBLICATIONS The Center for Liver Diseases has been active with a large number of publications and presentations. In 2006, the center has had 26 articles published submitted. Since its inception CLD has published at total of 110 articles book chapters and presented 86 research presentation to international scientific meetings. In 2007, Dr. Younossi will complete a textbook in Hepatology which will be published by Cambridge Press. Additionally, he will be the Guest Editor of an issue of Clinics in Liver Diseases on Nonalcoholic steatohepatitis which will be published by Elsevier. The details of our publications and presentation are summarized below and a few examples of our publications are provided: Books, Chapters and Supplements 2000-Present ; 1. 2. 3. Baranova, L Liotta, E Petricoin New Technologies in the Study of Liver Diseases. Clinician's Guide for Common Liver Disease. Cambridge Press 2007 J Ong, Z Younossi Epidemiology and Natural History of NAFLD and NASH. Clinics in Liver Disease 2007 P Mishra, Z Younossi Non-Alcoholic Fatty Liver Disease. Clinician's Guide for Common Liver Disease. Cambridge Press 2007 Z Younossi Clinician's Guide for Common Liver Diseases Author Editor ; , Cambridge Press, 1st edition, 2007 Z Younossi Non-alcoholic Steatohepatitis and Non-alcoholic Fatty Liver Disease, Clinics in Liver Disease Guest Editor ; , 2007. |
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Distribution of claimants therapeutic class number of claimants antibiotics respiratory drugs analgesics and antiinflammatory drugs acne drugs contraceptives stimulants antidepressants antipsychotic agents anti-convulsant agents gastrointestinal agents antidiabetic drugs all drugs total ; 780, 684 182, share of total claimants 76% 18% 8% distribution of prescriptions number of share of total prescriptions prescriptions 1, 740, 446 prescriptions per claimant, for example, hcl.
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P4494 Comparison of bronchial washing, brushing and biopsy in 939 cases in cardiothoracic centre Liverpool ; Keiumars Maleki 1 , Martin Ledson 2 . 1 Respiratory Medicine, Countess of Chester Hospital, Chester, Cheshire, United Kingdom; 2 Respiratory Medicine, Cardiothoracic Centre, Liverpool, Mersyside, United Kingdom Background: Lung cancer is the commonest cause of death in the UK, and bronchoscopy is usually the first choice investigation tool in lung cancer. Objective: comparing cytology and biopsy results and to evaluate the diagnostic value of washing and brushing in diagnosis of lung cancer. Methods: Results of 939 cases 527 male and 402 female ; of bronchoscopy which were carried out between April 2000 and June 2004 were evaluated and keftab.
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Arrow Pharmaceuticals Ltd v Merck & Co Inc [2004] FCA 1282. Lek Pharmaceutical and Chemical Company DD v Smithkline Beecham plc [2004] APO 10 14 May 2004 ; . Shino Kaneko v Nemoto &Co Ltd 2004 ; APO 17 12 July 2004 ; . Prabuddah Ganguli, 'Global Pharmaceutical industry: intellectual wealth and asset protection' International Journal of Technology Management 2003 ; 25 3 4 ; , 284.
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Luckmann R. Evidence-Based Medicine. March-April 2001. Vol.6. No.2. p.43. Reviewed by Dr Bruce Arroll.
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References 1. Current Problems in Pharmacovigilance September 2003; Volume 29: 1-3 2. Consensus Statement on Hormone Replacement Therapy HRT ; , Royal College of Physicians of Edinburgh, October 2003 : rcpe.ac esd consensus hrt 03 . Accessed 05 11 03, reproduced with permission. 3. Lancet 2003; 362: 419-427 Chlebowski RT et al. JAMA 2003; 289 24 ; : 3243-3253 5. S. Evans. Manuscript in preparation 6. Beral V. et al Lancet 2002; 360: 942-944 Menopause 2003; 10: 465-476 The Women's Health Initiative Steering Committee. JAMA 2004; 291: 1701-12.
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Tables 1. Questionnaires Completed by Age, Gender and Primary Care Trust 2004 05 2. Comparison of Quit Rates 3. Analysis of Quitters by Gender, 2004 05 4. Analysis of Quitters by Age, 2004 05 5a. Analysis of Male Quitters by Age, 2004 05 5b. Analysis of Female Quitters by Age, 2004 05 6. Analysis of Quitters by PCT, 2004 05 7. Main Reasons for Wanting to Give up Smoking? 8. Products Used to Stop Smoking 9. Main Reasons Given for Restarting Smoking 10. Method of First Contact with the Stop Smoking Service 11. First Awareness of the Stop Smoking Service 12. Main Contact When Using the Stop Smoking Service 13. Frequency of Contact with the Stop Smoking Service 14. Perceived Helpfulness of the Stop Smoking Services 15. Aspects of the Stop Smoking Services Considered Helpful 16. Analysis of Quitters by Type of Intervention, 2004 05 17. Awareness of Pirate FM Campaign Page 9.
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The new radiopharmaceutical 4-iodo-2, 5-dimeth oxyphenylisopropylamine, 4-1-DPIA, is of interest not only as an agent for positive imaging of normal brain, but also for studies of the mode of action of psychodysleptic drugs and their relation to the meta bolic basis of schizophrenia. The uptake of 4-1-DPIA in the brain of the.
BIOLOGY OF RNA INTERFERENCE: STABILITY, DELIVERY AND PROCESSING BY TISSUES RFA-HL05-019 ; Letter of Intent Receipt Date: December 21, 2005 Application Receipt Date: January 18, 2006 : grants.nih.gov grants guide rfa-files RFA-HL-05-019 NOTICE OF INTENT TO PUBLISH A REQUEST FOR APPLICATIONS RFA ; TITLED: SOCIAL NEUROSCIENCE NOT-DA-05-011 ; National Institute on Drug Abuse : grants.nih.gov grants guide notice-files NOT-DA-05-011 NOTICE OF INSTITUTIONAL CLINICAL AND TRANSLATIONAL SCIENCE AWARD RFA AND PRESUBMISSION MEETING NOT-RM-05-013 ; NIH Roadmap Initiatives National Center for Research Resources : grants.nih.gov grants guide notice-files NOT-RM-05-013 COMPLETION OF A COMPREHENSIVE MOUSE KNOCKOUT RESOURCE RFA-HG-05-007 ; National Human Genome Research Institute National Cancer Institute National Center for Research Resources National Eye Institute National Heart, Lung, and Blood Institute National Institute on Aging National Institute on Alcohol Abuse and Alcoholism National Institute of Arthritis and Musculoskeletal and Skin Diseases National Institute of Child Health and Human Development National Institute on Drug Abuse National Institute on Deafness and Other Communication Disorders National Institute of Dental and Craniofacial Research National Institute of Environmental Health Sciences National Institute of Mental Health National Institute of Neurological Disorders and Stroke Application Receipt Date s ; : November 22, 2005 : grants.nih.gov grants guide rfa-files RFA-HG-05-007 A DATA COORDINATION CENTER FOR THE KNOCKOUT MOUSE PROJECT KOMP ; RFA-HG-05-008 ; National Human Genome Research Institute Application Receipt Date s ; : November 22, 2005 : grants.nih.gov grants guide rfa-files RFA-HG-05-008 COLLABORATIVE RESEARCH ON MENTAL AND NEUROLOGICAL DISORDERS RFA-MH-06-003 ; National Institute of Mental Health National Institute of Neurological Disorders and Stroke Application Receipt Date s ; : November 18, 2005 : grants.nih.gov grants guide rfa-files RFA-MH-06-003 NINDS EXPLORATORY DEVELOPMENTAL PROJECTS IN TRANSLATIONAL RESEARCH PAR-05-157 ; National Institute of Neurological Disorders and Stroke Application Receipt Date s ; : Multiple dates, see announcement. : grants.nih.gov grants guide pa-files PAR-05-157 NINDS COOPERATIVE PROGRAM IN TRANSLATIONAL RESEARCH PAR-05-158 ; National Institute of Neurological Disorders and Stroke Application Receipt Date s ; : Multiple dates, see announcement. : grants.nih.gov grants guide pa-files PAR-05-158. Oral contraceptives and minipills for use as emergency contraception are easy to prescribe since no physical exam is necessary. Some clinicians may prescribe them by phone to established clients, enabling women to have faster, easier access to emergency contraception and eliminating the cost of an office visit. Clinicians may also prescribe emergency contraception for women to keep at home in the event it is ever needed. A recent study demonstrated that women who had advance provision of emergency contraception were more likely than those randomized to receive emergency contraceptive pills only if they asked for treatment, to use emergency contraceptive pills once, but not repeatedly. The advance-provision group also had a lower rate of unintended pregnancy.
References 1. Pennisi, E., Science, 276, 227 1998 ; . 2. Shenk, D., The Nation, 268, 11 1999 ; . 3. Vogel, G., Science, 276, 523-525 1998 ; . 4. Dong, B.J., J. Amer. Med. Assoc., 277, 1205-1213 1997 ; . 5. Phillips, R. and J. Hoey, Can. Med. Assoc. J., 159, 955-957 1998 ; . 6. Kern, D., Int. J. Occup. Environ. Health, 4, 19-32 1998 ; . 7. Blumenthal, D., Campell, E., Anderson, M., Causino, N. and Seashore, K., J. Amer. Med. Assoc., 277, 1224-1228 1997.
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