The rarity of the occurrence of this condition has resulted in the total ignorance of the management of the condition; also there are many more cases that go unreported. At this stage the author wishes to describe a case of her own wherein the genesis of HMCLF was traced from its inception. A 24 year old infertile woman became pregnant after induction of ovulation with clomiphene citrate and timed administration of human chorionic gonadotropin followed by intrauterine insemination of husband's spermatozoa. She was scanned on the 46th day of amenorrhoea 9 4 93 ; when twin gestational sacs were seen with the presence of foetal heart in one sac. A second scan one week later 53rd day ; showed that one sac had.
Rahier A and Taton M 1996 ; Sterol biosynthesis: strong inhibition of maize 5, 7sterol 7-reductase by novel 6-aza-B-homosteroids and other analogues of a presumptive carbocationic intermediate of the reduction reaction. Biochemistry 35: 7069 7076. Ramsey RB, Fredericks M, and Fischer VW 1977 ; Effect of zuclomiphene on cholesterol formation in the developing central nervous system of the rat. J Neurochem 28: 13171321. Scallen TJ, Condie RM, and Schroepfer GJ 1961 ; Inhibition by triparanol of cholesterol formation in the brain of the newborn mouse. J Neurochem 9: 99 103. Schloss JV 1988 ; Significance of slow-binding enzyme inhibition and its relationship to reaction-intermediate analogues. Accounts Chem Res 21: 348 353. Schmidt GE, Moon HK, Mansour R, Torello L, and Friedman CI 1986 ; The effects of enclomiphene and zuclomiphene citrates on mouse embryos fertilized in vitro and in vivo. J Obstet Gynecol 154: 727736. Silve S, Dupuy PH, Labit-Lebouteiller C, Kaghad M, Chalon P, Rahier A, Taton M, Lupker J, Shire D, and Loison G 1996 ; Emopamil-binding protein, a mammalian protein that binds a series of structurally diverse neuroprotective agents, exhibits 8- 7 isomerase activity in yeast. J Biol Chem 271: 22434 22440. Taton M and Rahier A 1991 ; Identification of 5, 7-sterol 7-reductase in higher plant microsomes. Biochem Biophys Res Commun 181: 465 473. van Sickle WA, Wilson PK, Wannamaker MW, Cooper JR, Flanagan MA, McCarthy JR, Bey P and Jackson RL 1993 ; An alternative mechanism for the inhibition of cholesterol biosynthesis in hepG2 cells by n-[ 1, 5, 9 ; -trimethyldecyl]-4 , 10dimethyl-8-aza-trans-decal-3 -ol MDL 28, 815 ; . J Pharmacol Exp Ther 267: 1243 1249. Watts CKW and Sutherland RL 1984 ; High affinity specific antiestrogen binding sites are concentrated in rough microsomal membranes of rat liver. Biochem Biophys Res Commun 120: 109 115.
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At the time of this exam, it will be necessary to examine the ovaries to determine if a cyst has developed, which would prevent you from taking clomiphene for the following cycle.
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Though organized media campaigns [12] aimed to increase PCOS awareness both among physicians and patients ; should result in more women seeking medical evaluation specifically because PCOS is suspected. As these laudable education efforts gain momentum, however, the current state of patient comfort with their "level of awareness" regarding PCOS, where their facts come from, and how they feel about their diagnosis are imprecisely characterized. If the objective of heightened public interest in PCOS is indeed achieved through wide publicservice announcements or other structured media exposure, then a contemporary baseline ; measurement of patient perception and awareness of PCOS as reported here would be helpful. Although we could not verify the self-reported cognitive claims made by study participants, more than half of respondents considered themselves to be "very aware" of PCOS. These data confirm an intuitive association between physicians and PCOS patient teaching through office-based patient education and counseling. That most women would turn first to their doctor for further guidance regarding PCOS is not a new finding, although these data indicate that the messages conveyed by doctors appears to be poorly received by patients. Specifically, the strongly negative emotions study participant identified with PCOS management by physicians demonstrated a profound gap between patient expectations and actual prescribed ; therapy. Indeed, our study population appeared unsatisfied with oral contraceptives or clomiphene citrate when prescribed as treatment for PCOS. In this study we were careful not to call specific attention to any substitute therapy, but rather to describe patient acceptance of these two existing treatments. This investigation detected a strong receptiveness among PCOS women regarding any safe and effective alternative to PCOS management. "Frustration" and "anxiety" associated with PCOS was observed across all age groups in this sample, perhaps suggesting either that a PCOS diagnosis was delayed in some older patients, or that negative emotions persist in some PCOS patients for many years after they are informed of their condition. As with any questionnaire-based research, there were some important limitations with our study that should be acknowledged. Our research method relied on an unscreened but motivated audience and a functional computer interface, with the result that PCOS patients lacking the means and or ability to access the study questionnaire were excluded from our sample. The fact that study participation depended on internet use likely explains the high self-reported familiarity and knowledge level for PCOS in this group. While PCOS preferen.
1 Hay CR. Acquired haemophilia. Baillieres Clin Haematol. 1998; 11: 287-303. Margolius A, Jackson DP, Ratnoff OD. Circulating anti-coagulants: a study of 40 cases and a review of the literature. Medicine Baltimore ; . 1961; 40: 145-202. Lottenberg R, Kentro TB, Kitchens CS. Acquired hemophilia. A natural history study of 16 patients with factor VIII inhibitors receiving little or no therapy. Arch Intern Med. 1987; 147: 1077-81. Hoyer LW, Gawryl MS, de la Fuente B. Immunological characterization of factor VIII inhibitors. Prog Clin Biol Res. 1984; 150: 73-85. Fulcher CA, de Graaf Mahoney S, Zimmerman TS. FVIII inhibitor IgG subclass and FVIII polypeptide specificity determined by immunoblotting. Blood. 1987; 69: 1475-80. Michiels JJ, Bosch LJ, van der Plas PM, Abels J. Factor VIII inhibitor postpartum. Scand J Haematol. 1978; 20: 97-107. Green D, Lechner K. A survey of 215 non-hemophilic patients with inhibitors to Factor VIII. Thromb Haemost. 1981; 45: 200-3. Hay CR, Negrier C, Ludlam CA. The treatment of bleeding in acquired haemophilia with recombinant factor VIIa: a multicentre study. Thromb Haemost. 1997; 78: 1463-7. Morrison AE, Ludlam CA, Kessler C. Use of porcine Factor VIII in the treatment of patients with acquired hemophilia. Blood. 1993; 81: 1513-20. Fantl P, Nance MH. An acquired haemorrhagic disease in a female due to an inhibitor of blood coagulation. Med J Aust. 1946; 2: 125-9. Shobeiri SA, West EC, Kahn MJ, Nolan TE. Postpartum acquired hemophilia factor VIII inhibitors ; : a case report and review of the literature. Obstet Gynecol Surv. 2000; 55: 729-37. Solymoss S. Postpartum acquired factor VIII inhibitors: results of a survey. J Hematol. 1998; 59: 1-4. Ries M, Wolfel D, Maier-Brandt B. Severe intracranial hemorrhage in a newborn infant with transplacental transfer of an acquired factor VIII: C inhibitor. J Pediatr. 1995; 127: 649-50. Hauser I, Schneider B, Lechner K. Post-partum factor VIII inhibitors. A review of the literature with special reference to value of steroid and immunosuppressive treatment. Thromb Haemost. 1995; 73: 1-5 and
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06 sep 2007 context: clomiphene citrate cc ; and metformin are two effective drugs used to induce ovulation in patients with polycystic ovary syndrome pcos ; , journal of clinical endocrinology and metabolism, fertility drugs don' t raise breast cancer risk: report - aug 10, 2007 after adjustment, the researchers found that clomiphene and four synthetic hormones used to boost fertility did not significantly affect the risk of breast scientific american fertility clinic: medicines for female infertility - jul 30, 2007 vanguard, perhaps by far the most common is clomiphene citrate clomid.
PEARLSTONE AC, FOURNET N, GAMBONE JC, PANG S, BUYALOS RP: Ovulation induction in women age 40 and older: the importance of basal follicle-stimulating hormone levels and chronological age. Fertil Steril 58: 674-9, 1992. WU TC, GELETY T, JIH M, FOURNET N, BUYALOS RP: Successful management of predicted severe ovarian hyperstimulation syndrome with gonadotropin-releasing hormone agonist. J Asst Reprod Genet 9: 281-6, 1992. BUYALOS RP, GEFFNER ME, WATANABE RM, BERGMAN RN, GORNBEIN JA, JUDD HL: The influence of luteinizing hormone and insulin on sex steroids and sex hormone-binding globulin in the polycystic ovarian syndrome. Fertil Steril 60: 626-33, 1993. GELETY TJ, BUYALOS RP: The effect of clomiphene citrate and menopausal gonadotropins on cervical mucus in ovulatory cycles. Fertil Steril 60: 471-6, 1993. AGARWAL SK, COE S, BUYALOS RP: The influence of uterine position on pregnancy rates with in vitro fertilization - embryo transfer. J Asst Reprod Genet 11 6 ; 323-4, 1994. BUYALOS RP, TSUI E, CAI X: Enhanced preimplantation embryo development by epidermal growth factor. J Asst Reprod Genet 11 1 ; 33-7, 1994. The Writing Group for the PEPI Trial: Effects of estrogen and estrogen progestin regimens on heart disease risk factors in postmenopausal women. JAMA 273 3 ; : 199-208, 1995. BUYALOS RP: Insulin-like growth factors: Clinical experience in ovarian function. J Med 98 1A ; : 55-66, 1995. BUYALOS RP. The role of follicle-stimulating hormone in infertility therapy. Assist Reprod Rev 5 1 ; : 45-52, 1995. AGARWAL S, BUYALOS RP: Corpus luteum function and pregnancy rates with clomiphene citrate therapy: comparison of human chorionic gonadotropin induced versus spontaneous ovulation. Human Reprod 10 2 ; : 328-31, 1995. BUYALOS RP, PEKONEN F, HALME J, JUDD H, RUTANEN E: The relationship between circulating androgens, obesity and hyperinsulinemia on serum insulin-like growth factor binding protein-1 in the polycystic ovarian syndrome. J Obstet Gynecol 172 3 ; : 932-9, 1995. UHLER M, BUYALOS RP: The effect of varying inseminating sperm concentrations in malefactor and non-male factor infertility in human in vitro fertilization. Int J Fertil 40 6 ; : 322-8, 1995. GELETY TJ, BUYALOS RP: The influence of supraphysiologic estradiol levels in human nidation. J Asst Reprod Genet 12 7 ; : 406-12, 1995. The Writing Group for the PEPI Trial: Effect of hormone replacement on endometrial histology in postmenopausal women. JAMA 275 5 ; : 370-5, 1996 and
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Code 12652, and accordingly the Qui Tam Plaintiff is entitled to proceed as a co-plaintiff with California in this action in which the Attorney General of California has intervened. IV. BACKGROUND OF HOW PRESCRIPTION DRUG CLAIMS ARE PAID UNDER MEDI-CAL A. 26. HOW THE SYSTEM WORKS IN CALIFORNIA California routinely provides prescription drug coverage as part of its Medi-Cal.
The simplest and easiest way to make sure that adequate progesterone is produced after ovulation is to give every woman on clomiphene a shot of hcg at the time of ovulation and combivir.
Blumberg's expert report. We note that the report was transmitted to counsel for Downey on or about August 23, 1999. In that report, Dr. Blumberg concluded only that, in his opinion, "to a reasonable degree of medical probability, " Gertrude Downey died "as a direct result of the deviation from the standard of care rendered by the staff of the [Medical Center]." Letter, 8 23 99 at 5, R.R. 32a. At no point in his report does Dr. 14.
When entering the profession, pilots need to be in better health than the general population. During their careers they are under close medical supervision which could influence their life-long mortality. During the ten-year period from 1992 to 2002 we examined 5 841 commercial and 8216 military pilots. There was no serious aircraft accident in the Czech Airlines and Czech Air Force due to medical reasons during this period. We registered several sudden deaths among the group of airline and military pilots. Nobody of these pilots had control of the aircraft, when they died, but one of them was just travelling to his duty. There were five sudden cardiovascular deaths, four times we found tumours, two times leukaemia. Acute pancreatitis, liver insufficiency and asthma bronchiole were found one time. The causes of sudden deaths are possible distinguished into two groups: 1. Pilots who try to hide their problems and diagnoses or they are treated by non-aviation doctors and during air-medical examinations do not inform any examiner about their problems 4 times in our group ; 2. Pilots who die due to possibility of unpredictable sudden deaths 9 times in our group ; . The probability of sudden death in our group was 0, 16%. It rises a question if the extent of medical examination is sufficient because we could grounded as minimum 4 persons 28, 6% ; and may be follow up them better. We did not discover the treat of the sudden death in 71, 4% ! CONCLUSIONS. 1 ; Since the year 2000 we implemented JAR-FCL rules and our pilots know very well the extension of examinations and do not want generally ; to extend their regular examinations. Our solution is that we offer them cardiovascular and anti-cancer preventive programmes which is for volunteers and it starts running and lamivudine.
Comment: there have been tens of thousands of pregnancies on clomiphene.
1. Limit food intake to slow further weight gain. Serve smaller portions of lean meats, grains, and starches. Encourage fresh or water-packed fruits and vegetables. Limit fatty meats, gravies, fried foods, sweets, desserts, and salad dressings. Change from whole to nonfat milk or at least mix equal parts together. Children younger than two years should be given whole milk unless a physician recommends lowfat or nonfat milk for that child. ; Dilute all beverages with extra water. 2. Encourage physical activity geared to the child's capability. This will not only increase energy expenditure but also provide good exercise experience. Overweight children often have not had the opportunity to develop motor skills. The severe peer discrimination further discourages their physical activities. 3. Avoid using food as a reward; try a sticker or star on a chart instead. If food rewards are absolutely necessary, use low-calorie foods suggested below. Nutritious, Low-Calorie Snacks for Little Ones and zidovudine.
CP55940, A NON-SELECTIVE CB1 CB2 AGONIST, STIMULATES BONE RESORPTION BY HUMAN OSTEOCLASTS IN VITRO Lauren Whyte1, 2, Susan Ridge1, Michael J Rogers1 and Ruth Ross2 Bone & Musculoskeletal Research Programme, Institute of Medical Sciences, School of Medicine1 and Medical Sciences2, University of Aberdeen, Scotland, AB25 2ZD Cannabinoid receptors CB1 and CB2 ; are G protein coupled receptors expressed in mammalian tissues and activated by endogenous cannabinoid ligands. Recent studies in mice have shown that cannabinoid receptors are present in bone, with both CB1 and CB2 knockout mice displaying altered bone phenotypes. Cannabinoid receptors are known to be expressed in human peripheral blood mononuclear cells but it is yet to be determined whether human osteoclasts express cannabinoid receptors. We sought to characterise the expression of CB1 and CB2 on human osteoclasts and to examine the effect of CP55940, a non-selective CB1 CB2 agonist. Human osteoclasts were generated by culturing peripheral blood-derived monocytes from healthy donors with M-CSF and RANKL. Using real-time PCR and western blotting, both monocytes and osteoclasts generated in vitro were found to express CB1 and CB2 receptor mRNA and protein. The level of CB1 did not appear to change throughout osteoclast differentiation, whereas the level of CB2 appeared to decrease during differentiation as has been reported during B cell differentiation ; . To study the effect of CP55940, osteoclasts were generated on plastic to study differentiation ; or on dentine discs to study resorptive activity ; in the continual presence of vehicle or CP55940. In the presence of 1nM-1M CP55940 there was no significant change in the number of VNR-positive osteoclasts; concentrations above 1M caused a decrease in osteoclast number, attributed to cytotoxicity. However, 1nM-1M CP55940 significantly increased the proportion of actively-resorbing osteoclasts i.e. cells with actin rings ; and increased resorption area e.g. at 1M, cells with actin rings were 229% + - 31 of control P 0.05 resorption area was 334% + - 50 of control P 0.01 ; , n 7 experiments. This demonstrates for the first time that this non-selective CB1 CB2 agonist stimulates the activity of human osteoclasts. This finding is consistent with recent studies showing that a CB1 antagonist prevents bone loss in OVX mice. Together, our observations confirm that CB1 and CB2 are expressed on human osteoclasts and suggest that endogenous ligands for these receptors may have direct effects on osteoclastic resorption. It remains to be determined whether the stimulatory effect of CP55940 is mediated via CB1 and or CB2, because clomphene citrate use.
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Because fetal losses following CVS are often higher than those for amniocentesis, efficacy analysis should be conducted assuming a 1.5 percent fetal loss risk attributable to invasive testing in the first trimester. With higher fetal losses, the efficacy of the prenatal screening is adversely affected, although the cost-effectiveness will not change. In addition, assuming a higher false-positive rate of 8.3 percent increases the number of invasive tests on unaffected mothers and the number of unaffected fetal losses, thus adversely affecting the efficacy of the prenatal testing Vintzileos and others 2000 ; . The analysis presented above is limited to an evaluation of the cost-effectiveness of prenatal screening for DS only. Some serum markers for example, alpha-fetoprotein ; will identify other abnormalities, the benefits of which are not included in this analysis. Equity and Access The desirable policy is that women of similar risk for DS have equal access to diagnostic tests. With limited access to prenatal care, the introduction of the screening programs can have small public health effects. Although the approach used in cost-effectiveness analysis is optimization of societal net benefit, the policies to be recommended for the prevention of disability must also consider individuals' freedom in decision making at each step of the prenatal diagnosis. Successful policies need to be based on cost-effectiveness.
Clomiphene treatment for infertility
Fertility treatment approaches several approaches can treat infertility, depending on the cause: lifestyle measures healthy lifestyle, planning sexual activity with ovulation cycle, managing stress and emotions ; treatments for endometriosis, fibroids, or menstrual disorders use of anti-estrogen drugs, such as clomiphene, to induce ovulation in women with ovarian dysfunction surgery standard or laparoscopic ; to unblock fallopian tubes use of hormone treatments clomkphene or progestins ; for luteal phase defect assisted reproductive technologies art ; such as in vitro fertilization ivf ; or intracytoplasmic sperm injection icsi ; choosing a fertility clinic choosing a good fertility clinic is important and
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May cause visual disturbance may cause ascites may cause bone marrow suppression may cause hot flushes treatment should not normally exceed 6 months should be used with caution in patients with polycystic ovary syndrome posted: sun feb 27, 2005 post subject: clomiphene.
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If a woman is menstruating, even if irregularly, clomiphene is usually effective.
Generally, clomiphene prepares a woman's body for pregnancy and
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It has been observed that in one out of five cases where clomiphene is administered, the egg remains trapped in the follicle after ovulation.
Cranial operation had been performed 13 months ago. His body weight and height were 39 kg and 1, 46 meter, respectively. Physical examination revealed that he was not face hair development, axillary and pubic hair development Stage G1, according to Marshall and Tanner Staging ; 11 ; . His left eye was cross-eyed. On genitourinary examination; penis height was 3 cm in passive extension ; , left and right testis size was 1 x 0.5 x 1.5 and 1 x 1 1.5 cm, respectively. His left lower and upper extremities were hemiatrophic Table 1 and Figure 1 ; . Motor deficit was not detected and electromyographic evaluation of upper and lower extremities was within normal limits. Hormone TSH ; [1.14 mIU mL 0.4-4.0 ; ], prolactin [3.95 ng mL 2.5-17 ; ], and cortisol levels were normal [8.79 ug dL 5-25 ; ]. Other laboratory examination; hemoglobin 13.6 g dL ; , plasma glucose 95 mg dL ; , sodium 139 mmol L ; , potassium 3.9 mmol L ; , creatinine 0.6 mg dL ; , calcium 9.2 mg dL ; , alanine transaminase 15 U L ; , aspartate transaminase 17 U l ; were within normal limits. After hospitalization; we evaluated GH reserve, pituitary-adrenal, and pituitary-gonadal systems. Normal GH response to insulin hypoglycemia testing and during sleeping were detected GH level was increased from 0.4 to 14.2 ng mL during sleeping and from 0.36 to 10.6 ng mL during the insulin hypoglycemia testing ; . These results indicate that normal response for GH in our patient. Pituitary-adrenal axis was evaluated by insulinhypoglycemia test and cortisol level was increased from 8.7 to 22 ug during the test. This response was accepted in normal limits. Clomphene citrate stimulation test was performed for the evaluation of hypathalamo-pituitary-gonadal system. FSH, LH, and testosterone was not increased after the test. Normal LH, FSH response was detected to Gonadotropin-releasing hormone test Table 2 ; . Testosterone levels was increased from 38 to 289 ng dL during the Chorionic Gonadotropin stimulation test. This response for testosterone was normal. Ultrasonographic examination of testes, right and left testes sizes were calculated 2.1 x 1.4 x 0.6 and 2.1 x 1.7 x 0.7 cm, respectively. Dilated third and lateral ventricles, tonsilar herniation and syringemyelia were detected by cranial and spinal magnetic resonance MR ; imaging Figures 2a, 2b ; . Pituitary MR imaging was normal.
Eonatal Intensive Care Units NICUs ; are high-technology hospital departments. Neonatologists have 24-hour access to computerized physiological data on a high-risk or premature infant's health status. Electronic monitors continually assess and report basics, such as temperature, blood pressure, and respiration. Doctors may request specialized high-tech testing to evaluate a baby's blood oxygenation, cardiac functions, and even vision and hearing capabilities. Equally important is the time and care that skilled and experienced physicians and compassionate staff give to each infant. Newborns' parents recognize the balance between the masses of high-tech NICU equipment and the quality time caregivers spend touching, talking to, and smiling at babies.
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22 three different treatment groups: verum acupuncture, placebo acupuncture and a control group. All three groups were pharmacologically treated with the antidepressant mianserin. The verum group received acupuncture at specific points considered effective in the treatment of depression. The placebo group was treated with acupuncture at non-specific locations and the control group received pharmacological treatment plus clinical management. Acupuncture was applied three times a week over a period of 4 weeks. Psychopathology was rated by judges blind to verum placebo conditions twice a week over 8 weeks. Results: Patients who experienced acupuncture improved slightly more than patients treated with mianserin alone. Conclusions: Additionally applied acupuncture improved the course of depression more than pharmacological treatment with mianserin alone. However, we could not detect any differences between placebo and verum acupuncture. [14, 14 cta-ecr-] 69- gera: 78601 di ra [CLINICAL OBSERVATION ON 35 CASES OF POLYCYSTIC OVARY SYNDROME TREATED WITH TONIFYING THE KIDNEY PLUS ACUPUNCTURE]. SANG HAILI. journal of tcm. 2000, 41 7 ; , 412 chi * ; . ref: 22 Tonifying the kidney plus acupuncture method was used for treatment of 35 cases of polycystic ovary syndrome treatment group ; . Bu Shen Huo Xue Capsules No. I II , III and IV were respectively administrated according to different syndrome types such as kidney deficiency accompanied with blood stasis and stagnation of phlegm and retention of heat in liver and gallbladder, and different time of menstrual cycle. Acupuncture treatment for promoting ovulation was carried out on the 12th day of menstruation. Results indicated that the cured rate was 48. 6% and 33. 3%. the total effective rate was 91. 4% and 80. 0% the ovulation rate was 82. 9% and 80. 0% the pregnancy rate was 42. 9% and 26. 7% recovering-normal rate of menstrual cycle was 94. 3% and 80. 8% in the treatment group and the Clomophene control group respectively. The treatment group in the clinical therapeutic effect, the pregnancy rate, recovering-normal rate of menstruation was significantly superior to those of the control group P 0. 05 [11, 02 or P 0. vide + rn-d$-ecr-] 70- gera: 71713 di ra TCM THERAPY WITH ACUPUNCTURE AND HERBAL MEDICINE IN THE TREATMENT OF PATIENTS WITH ALLERGIC RHINITIS : A RANDOMISED CONTROLLED TRIAL abstract ; . SEUFERT J ET AL. deutsche zeitschrift fur akupunktur. 2000, 43 1 ; , 41 eng ; . [16, 04 ecr-cta-] 71- gera: 73006 di ra ACUPUNCTURE TREATMENT OF PREMATURE OVARIAN FAILURE OBSERVATION OF 76 CASES. SHA GUI-E ET AL. international journal of clinical acupuncture. 2000, 11 1 ; , 11 eng ; . ref: 0 Premature ovarian failure refers to amenorrhea occurring in a woman under 40 years of age, mostly due to a low level of estrogens and high gonadotropins Gn ; , from which disorders of vegetative nerve, dysfunction of regenerative and sexual functions, atrophy of regenerative organs and loss of the secondary sex signs are present. In TCM, it pertains to the catalogue of amenorrhea or irregular menstruation, commonly seen in clinics and is mostly due to deficiency of Liver.
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