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Social hygiene service, under the Department of Health, is a public institution to treat patients with dermatological diseases, STIs and leprosy. One of the major aims of the service is to provide effective control of STIs through accurate diagnosis, effective treatment, contact tracing and health education and counselling. The service is totally free of charge and no referral letter is required. Confidentiality is strictly kept for each patient. In Hong Kong, STIs are not notifiable communicable diseases and thus there would be no officially reported incidence. Since over 80% of the STIs were diagnosed and treated in the private sector, the statistical data provided by Social Hygiene Service only reflect part of the actual incidence of STIs in Hong Kong.9 From 1991 to 2000, the incidences of all types of STIs increased from 12, 446 to 28, 541 for all patients and from 394 to 976 for adolescent patients age 13 to 19 ; Figure 1 ; . The increment in both adult and adolescent groups was largely due to the increase in incidence of nongonococcal urethritis in male and non-specific genital infection in female Figure 2 ; , which are defined as equal or more than 10 pus cells per high power field in the urethral and or more than 30 pus cells in the cervical gram-stained smears without evidence of gonorrhoea. This category of disease is predominantly caused by genital chlamydial trachomatis infection. A gradual rising trend of the incidences of genital wart Figure 3 ; and early syphilis Figure 4 ; in adolescents was also noted. On the other hand, the incidence of gonorrhoea Figure 5 ; remained steady in the early nineties, which then declined in the mid-nineties and subsequently showed an upward trend after 1998. The incidence of genital herpes in adolescents was quite steady over the past decade and ranged from 3 to 15 patients per year. The top five major STIs in male and female adolescent patients were shown in Table 1. The ranking order of the adolescent group was similar to the adult group. Order to improve the delivery of healthcare, because order aldara. Seek medical attention right away if any of these severe side effects occur: severe allergic reactions rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue back pain; breast discharge or lump in the breast; calf or leg pain or swelling; chest pain; coughing up blood; dark urine; depression; dizziness; fainting; fever; memory problems; mental or mood changes; muscle pain; one-sided weakness; painful or difficult urination; persistent or severe breast pain or tenderness; persistent or severe headache, nausea, or vomiting; severe stomach pain or swelling; slurred speech; sudden shortness of breath; sunburn-like rash; swelling of hands, legs, or feet; unusual vaginal bleeding, discharge, itching, or odor; vision changes; vomiting; weakness or numbness of an arm or leg; yellowing of the skin or eyes and alendronate.

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129. Delbosc S, Morena M, Djouad F, Ledoucen C, Descomps B, Cristol JP. Statins, 3hydroxy-3-methylglutaryl coenzyme A reductase inhibitors, are able to reduce superoxide anion production by NADPH oxidase in THP-1-derived monocytes. J Cardiovasc Pharmacol. 2002; 40 4 ; : 611-7. 130. Rueckschloss U, Galle J, Holtz J, Zerkowski HR, Morawietz H. Induction of NAD P ; H oxidase by oxidized low-density lipoprotein in human endothelial cells: antioxidative potential of hydroxymethylglutaryl coenzyme A reductase inhibitor therapy. Circulation. 2001; 104 15 ; : 1767-72. 131. Hattori Y, Nakanishi N, Kasai K. Statin enhances cytokine-mediated induction of nitric oxide synthesis in vascular smooth muscle cells. Cardiovasc Res. 2002; 54 3 ; : 649-58. 132. Bermudez EA, Rifai N, Buring JE, Manson JE, Ridker PM. Relation between markers of systemic vascular inflammation and smoking in women. J Cardiol. 2002; 89: 1117-9. Ross R. Atherosclerosis--an inflammatory disease. N Engl J Med. 1999; 340 2 ; : 11526. 134. Kubes P, Suzuki M, Granger DN. Nitric oxide: an endogenous modulator of leukocyte adhesion. Proc Natl Acad Sci U S A. 1991; 88: 4651-5. Collins RG, Velji R, Guevara NV, Hicks MJ, Chan L, Beaudet AL. P-Selectin or intercellular adhesion molecule ICAM ; -1 deficiency substantially protects against atherosclerosis in apolipoprotein E-deficient mice. J Exp Med. 2000; 191 1 ; : 189-94. 136. Petzelbauer P, Pober JS, Keh A, Braverman IM. Inducibility and expression of microvascular endothelial adhesion molecules in lesional, perilesional, and uninvolved skin of psoriatic patients. J Invest Dermatol. 1994; 103: 300-5. Groves RW, Ross EL, Barker JN, MacDonald DM. Vascular cell adhesion molecule-1 VCAM-1 ; . Expression in normal and diseased skin and regulation in vivo by interferon gamma. J Acad Dermatol. 1993; 29: 67-72. Huang KC, Chen CW, Chen JC, Lin WW. HMG-CoA reductase inhibitors inhibit inducible nitric oxide synthase gene expression in macrophages. J Biomed Sci. 2003; 10: 396-405. Morigi M, Angioletti S, Imberti B, Donadelli R, Micheletti G, Figliuzzi M, Remuzzi A, Zoja C, Remuzzi G. Leukocyte-endothelial interaction is augmented by high glucose concentrations and hyperglycemia in a NF-kB-dependent fashion. J Clin Invest. 1998; 101: 1905-15.

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